In the Reward and Addictive Disorders (RAD) Lab we use animal models to study motivational brain circuits on a systems level. Our goal is to understand how these neural circuits function in a healthy state as well as to uncover adaptations that contribute to maladaptive behaviors such as addiction. To address these questions, we study inflexible and compulsive reward-seeking behaviors in mice. We employ both pharmacological and genetic approaches to manipulate and uncover the neural circuits responsible for these behaviors.